We are going to have a bioinformatics journal club next Friday. In this semester, the journal club series will be held in every two weeks like before, but in Fridays from 1:00 pm to 2:00 pm.

Date:   17 February 2012 (Friday)
Time:   1:00 pm -- 2:00 pm
Venue:   Room 1021, Ho Sin-Hang Engineering Building
Speaker: Dr. Raymond Wan
Paper:   Pinho et al., "GReEn: a tool for efficient compression of genome resequencing data", Nucleic Acids Research (2011).
Abstract:
Research in the genomic sciences is confronted with the volume of sequencing and resequencing data increasing at a higher pace than that of data storage and communication resources, shifting a significant part of research budgets from the sequencing component of a project to the computational one. Hence, being able to efficiently store sequencing and resequencing data is a problem of paramount importance. In this article, we describe GReEn (Genome Resequencing Encoding), a tool for compressing genome resequencing data using a reference genome sequence. It overcomes some drawbacks of the recently proposed tool GRS, namely, the possibility of compressing sequences that cannot be handled by GRS, faster running times and compression gains of over 100-fold for some sequences. This tool is freely available for non-commercial use at ftp://ftp.ieeta.pt/～ap/codecs/GReEn1.tar.gz.